Thiourea-Catalyzed Enantioselective Hydrophosphonylation of Imines: Practical Access to Enantiomerically Enriched α-Amino Phosphonic Acids
| Autor: | Guy Joly, Eric N. Jacobsen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
inorganic chemicals
organic chemicals Imine Enantioselective synthesis Homogeneous catalysis General Medicine General Chemistry Biochemistry Catalysis chemistry.chemical_compound Colloid and Surface Chemistry chemistry Thiourea Hydrogenolysis polycyclic compounds Catalyst selectivity Organic chemistry heterocyclic compounds |
| Zdroj: | Journal of the American Chemical Society. 126:4102-4103 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja0494398 |
| Popis: | Chiral thiourea 1b catalyzes the highly enantioselective hydrophosphonylation of a wide range of N-benzyl imines. The hydrophosphonylation products are readily deprotected by hydrogenolysis, providing access to free alpha-amino phosphonic acids in highly enantioenriched form. |
| Databáze: | OpenAIRE |
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