Reversal of startle gating deficits in transgenic mice overexpressing corticotropin-releasing factor by antipsychotic drugs
| Autor: | Lucianne Groenink, Jocelien D A Olivier, Mark A. Geyer, Berend Olivier, Jan van der Gugten, P. Monika Verdouw, Anneloes Dirks, Koen G.C. Westphal |
|---|---|
| Přispěvatelé: | Groningen Institute for Evolutionary Life Sciences, Olivier lab |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
Startle response Reflex Startle Inhibition (Psychology) Corticotropin-Releasing Hormone medicine.medical_treatment Inbred Strains Gating Transgenic Mice Haloperidol Prepulse inhibition Clozapine medicine.diagnostic_test Behavior Animal Depression Startle Stimulation Chemical Psychiatry and Mental health Inhibition Psychological Drug Psychology hormones hormone substitutes and hormone antagonists medicine.drug Antipsychotic Agents medicine.medical_specialty endocrine system medicine.drug_class Atypical antipsychotic Mice Inbred Strains Mice Transgenic Chemical Dose-Response Relationship Cognitive neurosciences [UMCN 3.2] Internal medicine Reflex medicine Animals Acoustic Antipsychotic Pharmacology Behavior Dose-Response Relationship Drug Animal Body Weight Typical antipsychotic Reflex Acoustic Disease Models Animal Endocrinology Acoustic Stimulation Disease Models Stimulation |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 28(10), 1790-1798. Nature Publishing Group Neuropsychopharmacology, 28, 1790-8 Neuropsychopharmacology, 28, 10, pp. 1790-8 |
| ISSN: | 0893-133x 0893-133X |
| Popis: | Item does not contain fulltext Chronically elevated levels of corticotropin-releasing factor (CRF) in transgenic mice overexpressing CRF in the brain (CRF-OE) appear to be associated with alterations commonly associated with major depressive disorder, as well as with sensorimotor gating deficits commonly associated with schizophrenia. In the present study, we tested the hypothesis that antipsychotics may be effective in normalizing prepulse inhibition (PPI) of acoustic startle in CRF-OE mice, which display impaired sensorimotor gating compared to wild-type (WT) mice. The typical antipsychotic haloperidol and atypical antipsychotic risperidone improved PPI in the CRF-OE mice, but were ineffective in WT mice. The atypical antipsychotic clozapine did not influence PPI in CRF-OE mice, but reduced gating in WT mice. This effect of clozapine in the CRF-OE mice may thus be regarded as a relative improvement, consistent with the observed effect of haloperidol and risperidone. As expected, the anxiolytic, nonantipsychotic chlordiazepoxide was devoid of any effect. All four compounds dose-dependently reduced the acoustic startle response irrespective of genotype. These results indicate that antipsychotic drugs are effective in improving startle gating deficits in the CRF-OE mice. Hence, the CRF-OE mouse model may represent an animal model for certain aspects of psychotic depression, and could be a valuable tool for research addressing the impact of chronically elevated levels of CRF on information processing. |
| Databáze: | OpenAIRE |
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