Construction and Characterization of a Mirror-Image l-DNA i-Motif
| Autor: | Yuanchen Dong, Lijin Xu, Yi Hua, Jiqian Wang, Bo Yang, Dongsheng Liu, Jianhan Ye, Yawei Sun |
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| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Stereochemistry Organic Chemistry DNA Hydrogen-Ion Concentration 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound chemistry Molecular Medicine Nucleic Acid Conformation Thermodynamics heterocyclic compounds Self-assembly Nucleotide Motifs Molecular Biology |
| Zdroj: | Chembiochem : a European journal of chemical biology. 21(1-2) |
| ISSN: | 1439-7633 |
| Popis: | The first thermally stable and pH-responsive quadruplex intercalated motif (i-motif) structure formed by l-DNA is presented. Although this l-type i-motif exhibits the same physiochemical properties as its d isomer, its inverted chirality and good enzymatic resistance potentially open the way to the development of new DNA materials of pharmaceutical and biological interest. |
| Databáze: | OpenAIRE |
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