Real-life use of Rivaroxaban in the Netherlands: data from the Xarelto for Prevention of Stroke in Patients with Atrial Fibrillation (XANTUS) registry
| Autor: | Marc A. Brouwer, Ron Pisters, Martin E.W. Hemels, Harry J.G.M. Crijns, P. A. G. Zwart, W. L. ten Holt, S. P. G. van Vugt, Paulus Kirchhof, Arif Elvan |
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| Přispěvatelé: | MUMC+: MA Cardiologie (9), Cardiologie, RS: CARIM - R2.01 - Clinical atrial fibrillation |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Original Article - E‑Learning Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] 030204 cardiovascular system & hematology WARFARIN Dabigatran 03 medical and health sciences 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center Rivaroxaban Internal medicine medicine ORAL ANTICOAGULATION 030212 general & internal medicine Dosing Stroke GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Non-VKA oral anticoagulation OUTCOMES business.industry Warfarin DABIGATRAN Atrial fibrillation RANDOMIZED CONTROLLED-TRIAL AF medicine.disease XANTUS APIXABAN 3. Good health Discontinuation ASPIRIN Cardiology Apixaban Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Netherlands Heart Journal, 25, 551-558 Netherlands Heart Journal, 25(10), 551-558. Bohn Stafleu van Loghum Netherlands Heart Journal, 25, 10, pp. 551-558 Netherlands Heart Journal |
| ISSN: | 1568-5888 |
| Popis: | Background The Xarelto for Prevention of Stroke in Patients with Atrial Fibrillation (XANTUS) registry investigated the safety and efficacy of the factor Xa inhibitor rivaroxaban. We studied the Dutch XANTUS cohort to a ssess drug safety and prescription patterns in the Netherlands.Methods The XANTUS registry was designed as a European prospective, observational study among patients with non-valvular atrial fibrillation. Major bleeding and all-cause mortality were assessed every three months during a 1-year follow-up period. In this Dutch sub-cohort we were also specifically interested in dosing regimens and the incidence and reasons for temporary or permanent discontinuation.Results Patients (n = 899) had a mean age of 69 (SD +/- 9) years and 64.8% were male. The median CHA2DS2-VASc score was 2 (IQR 2-4) and the median HAS-BLED score was 2 (IQR 1-2). Major bleeding occurred in 19 patients (2.4 per 100 patient-years) and 8 patients (1.0 per 100 patient- years) died during the 1-year follow-up period. According to renal function, label-discordant dosing was observed in 48 (8.3%) patients. Finally, 124 patients (13.8%) reported a temporary interruption of rivaroxaban treatment and 11.8% switched to another oral anticoagulant therapy after permanent discontinuation of rivaroxaban.Conclusion In the Dutch subset of the XANTUS registry, we observed low rates of major bleeding and label-discordant dosing and high persistence rates during one year of follow-up in patients receiving rivaroxaban in routine clinical practice. However, documenting the motivation of novel oral anticoagulant (NOAC) type and dose is essential to study label-discordant prescription, a potential safety paradox and identify patient characteristics to optimise NOAC use and adherence. |
| Databáze: | OpenAIRE |
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