Cutaneous sebaceous tumours and Lynch syndrome: long‐term follow‐up of 60 patients
| Autor: | R.M. Penín, J. Marcoval, R. Fornons-Servent, Octavio Servitje, A. Talavera-Belmonte, A. Bauer-Alonso |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adenoma
Adult Male Urologic Neoplasms medicine.medical_specialty Lung Neoplasms Long term follow up Population Breast Neoplasms Nevus Sebaceous of Jadassohn Dermatology Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences Age Distribution 0302 clinical medicine Germline mutation Internal medicine medicine Humans Sebaceous Gland Neoplasms education Aged Retrospective Studies Aged 80 and over Carcinoma Transitional Cell education.field_of_study business.industry Incidence (epidemiology) Adenocarcinoma Sebaceous Prostatic Neoplasms Mean age Middle Aged medicine.disease Lynch syndrome Lynch Syndrome II Tumor Burden Keratoacanthoma Muir-Torre Syndrome Spain 030220 oncology & carcinogenesis Colonic Neoplasms Female business |
| Zdroj: | Clinical and Experimental Dermatology. 44:506-511 |
| ISSN: | 1365-2230 0307-6938 |
| Popis: | BACKGROUND Sebaceous neoplasms (SN) may appear sporadically in the general population but may also be part of the Muir-Torre variant of Lynch syndrome (MT-LS). There are few studies in southern Europe on the incidence of MT-LS in the population of patients with SN. AIM To retrospectively review patients with SN and to analyse their clinical features and the incidence of MT-LS. METHODS Patients with SN diagnosed between 1995 and 2015 were enrolled in the study. The diagnosis of MT-LS was made according to established clinical criteria and, whenever possible, was confirmed by germline mutation analysis. RESULTS In 60 patients (32 men, 28 women, mean age 69.22 years), 96 SN were diagnosed: 65 adenomas (67.7%), 16 sebaceomas (16.7%) and 15 carcinomas (15.6%). Of the 60 patients, 50 (83.3%) had a single SN and 10 (16.7%) had multiple lesions. Patients diagnosed with MT-LS (12 patients, 20%) were younger (63.25 years vs. 70.71 years), and had a higher incidence of extrafacial SN (4/12 patients, 33.3%), and were significantly (P |
| Databáze: | OpenAIRE |
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