Two‐dimensional separation techniques using supercritical fluid chromatography

Autor: Mahmoud Elhusseiny Mostafa, Samantha A. Calvez, James L. Edwards, James P. Grinias, Alexander S. Kaplitz
Rok vydání: 2020
Předmět:
Zdroj: Journal of Separation Science. 44:426-437
ISSN: 1615-9314
1615-9306
Popis: High resolution separation systems are essential for the analysis of complex mixtures in a wide variety of application areas. To increase resolution, multidimensional chromatographic techniques have been one key solution. Supercritical fluid chromatography provides a unique opportunity in these multidimensional separations based on its potential for high solvent compatibility, rapid duty cycles, and orthogonality to other separation modes. This review focuses on two-dimensional chromatography methods from the past decade that use supercritical fluid chromatography because of these advantages. Valving schemes and modulation strategies used to interface supercritical fluid chromatography with other LC and GC techniques are described. Particular applications of multidimensional separations using supercritical fluid chromatography for the analysis of oils and chiral separations of pharmaceutical compounds are highlighted. Limitations of and a potential trajectory for supercritical fluid chromatography in this field are also discussed. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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