Penetration of fimbriate enteric bacteria through basement membranes: A hypothesis

Autor:	T K, Korhonen, R, Virkola, K, Lähteenmäki, Y, Björkman, M, Kukkonen, T, Raunio, A M, Tarkkanen, B, Westerlund
Rok vydání:	1992
Předmět:	Enterobacteriaceae Fimbriae Bacterial Genetics Animals Humans Plasminogen Fibrinolysin Models Biological Molecular Biology Microbiology Bacterial Adhesion Basement Membrane
Zdroj:	FEMS Microbiology Letters. 100:307-312
ISSN:	1574-6968 0378-1097
Popis:	A mechanism for penetration of basement membranes by Escherichia coli is presented. The mechanism is based on the ability of the S fimbriae of meningitis-associated E. coli to bind to vascular endothelium and choroid plexuses in brain and to basement membranes. On the other hand, the S and the type 1 fimbriae of E. coli immobilize plasminogen and tissue-type plasminogen activator; this process generates proteolytic plasmin activity on the surface of fimbriate cells. Our hypothesis is that bacterium-bound plasma activity, directed to basement membranes through fimbrial binding, promotes bacterial penetration through basement membranes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a87df76940803108ec266b92988964c https://doi.org/10.1111/j.1574-6968.1992.tb05720.x Zobrazit plný text záznamu Plný text