Urinary leukotriene e4 level profile in various degrees of severity in atopic dermatitis patients in dermatovenereology outpatient clinic Dr. Soetomo General Hospital, Surabaya: A descriptive study
| Autor: | M. Marsoedi Hoetomo, Meita Ardini Pratamasari, Afif Nurul Hidayati |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Leukotriene Leukotriene E4 atopic dermatitis medicine.drug_class Leukotriene receptor business.industry Urinary system degrees of severity Dermatology Atopic dermatitis lcsh:RL1-803 medicine.disease urinary leukotriene E4 levels chemistry.chemical_compound chemistry Internal medicine medicine lcsh:Dermatology Corticosteroid Outpatient clinic business Asthma |
| Zdroj: | Dermatology Reports, Vol 11, Iss 1s (2019) |
| ISSN: | 2036-7406 2036-7392 |
| Popis: | Atopic dermatitis (AD) is a chronic, relapsing skin inflammatory disease. Corticosteroid as the cornerstone treatment for AD has some flaw, especially for the chronic recalcitrant AD, since it has side effects and high possibility of rebound. Leukotriene receptor antagonist (LTRA) which has been used for asthma and allergic rhinitis now has been developed for treating AD, based on the similar mechanism of inflammation. Leukotriene (LT) is an inflammatory mediator that is thought to play role in the asthma, allergic rhinitis, and AD. Urinary leukotriene E4 (U-LTE4), the stable metabolite of LT, can be found in urine. This research aims to evaluate the role of LT in various degrees of severity in AD patients by measuring U-LTE4 levels using Enzyme Linked Immunosorbent Assay (ELISA). Twenty two AD patients who were in a flare state and came to the outpatient clinic on April – July 2017 were measured their U-LTE4 levels. The results demonstrated that mean of U-LTE4 levels increases consistently with intensity of the degree of severity, and this finding supports previous study that LT plays role in AD. |
| Databáze: | OpenAIRE |
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