Preservation of myocardial viability within the risk area by intravenous nicorandil before primary coronary intervention in patients with acute myocardial infarction
| Autor: | Michio Shimojo, Tetsuro Sugiura, Seishi Nakamura, Yoshiaki Tsuka, Shigeo Umemura, Masato Baden, Toshiji Iwasaka |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Vasodilator Agents Myocardial Infarction Perfusion scanning Risk area Organophosphorus Compounds Internal medicine medicine Humans Radiology Nuclear Medicine and imaging In patient cardiovascular diseases Myocardial infarction Angioplasty Balloon Coronary Nicorandil Aged Tomography Emission-Computed Single-Photon business.industry Myocardium Percutaneous coronary intervention General Medicine Organotechnetium Compounds Middle Aged medicine.disease Functional recovery surgical procedures operative Conventional PCI Acute Disease Multivariate Analysis cardiovascular system Cardiology Female Radiopharmaceuticals business medicine.drug |
| Zdroj: | Nuclear medicine communications. 29(11) |
| ISSN: | 0143-3636 |
| Popis: | OBJECTIVE To investigate the cardioprotective effect of intravenous nicorandil before primary percutaneous coronary intervention (PCI) on preservation of myocardial viability, we studied 199 consecutive patients with acute myocardial infarction. METHODS Nicorandil was given intravenously on admission (before primary PCI). Echocardiography and technetium-99m tetrofosmin perfusion imaging were performed before and 1 month after primary PCI. Echocardiographic asynergic score before primary PCI was used to define the size of risk area, whereas the sum of scintigraphic defect grade before primary PCI was used to estimate myocardial viability within the area at risk. The change (before primary PCI and 1 month after primary PCI) in asynergic score and scintigraphic salvage index were calculated. RESULTS Patients were divided into nicorandil (n=101) and control (n=98) groups. Although asynergic score before primary PCI was not different between the two groups (nicorandil=3.5+/-2.1 and control=3.9+/-1.5), myocardial viability was preserved in nicorandil group (defect score=11.0+/-4.0) than that in control group (defect score=14.0+/-4.7, P |
| Databáze: | OpenAIRE |
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