The Association Between β-Blocker Use and Cardiorespiratory Fitness: The Maastricht Study
| Autor: | Frank de Vries, Miranda T. Schram, Coen D.A. Stehouwer, Hans H.C.M. Savelberg, Johannes T H Nielen, Ronald M.A. Henry, Pieter C. Dagnelie, Annemarie Koster, Annelies Boonen, Bart J F van den Bemt, Nicolaas C. Schaper, Jeroen H. P. M. van der Velde |
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| Přispěvatelé: | Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Farmacologie en Toxicologie, MUMC+: DA KFT Medische Staf (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Nutrition and Movement Sciences, RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, Interne Geneeskunde, MUMC+: MA Endocrinologie (9), RS: CAPHRI - R2 - Creating Value-Based Health Care, RS: CARIM - R3.02 - Hypertension and target organ damage, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), MUMC+: MA Reumatologie (9), Sociale Geneeskunde, RS: CAPHRI - R4 - Health Inequities and Societal Participation, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, RS: CARIM - R3 - Vascular biology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male BISOPROLOL medicine.medical_specialty PINDOLOL Time Factors PREDICTION Health Status Adrenergic beta-Antagonists Walk Test 030204 cardiovascular system & hematology Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] 03 medical and health sciences beta-blockers MAXIMAL OXYGEN-UPTAKE All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Predictive Value of Tests work load Internal medicine Clinical Studies medicine Humans Pharmacology (medical) 030212 general & internal medicine Prospective Studies Association (psychology) OLDER-ADULTS Aged Netherlands Pharmacology Exercise Tolerance cardiorespiratory fitness business.industry NEBIVOLOL Cardiorespiratory fitness Middle Aged DIFFERENCE Bicycling SELECTIVITY DISTANCE β-blockers Female business Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of Cardiovascular Pharmacology and Therapeutics, 24(1), 37-45. SAGE Publications Inc. Journal of Cardiovascular Pharmacology and Therapeutics Journal of Cardiovascular Pharmacology and Therapeutics, 24, 1, pp. 37-45 Journal of Cardiovascular Pharmacology and Therapeutics, 24(1), 37. SAGE Publications Ltd Journal of Cardiovascular Pharmacology and Therapeutics, 24, 37-45 |
| ISSN: | 1074-2484 |
| Popis: | Purpose: β-Blockers (BBs) have been associated with a reduced cardiorespiratory fitness (CRF). This is possibly caused by inhibition of β2-receptors in the airways. However, there are limited data available on β-receptor selectivity and CRF. We therefore aimed to assess the association between BB use and CRF and to assess the association between β-receptor selectivity and CRF. Methods: Participants in the Maastricht Study were aged between 40 and 75 years. Exposure to BB use was determined by use of pharmacy records. General linear models were used to obtain adjusted means of 2 proxies for CRF: covered distance during the 6-minute walk test (6MWT) and estimated maximum power output adjusted for body mass ( Wmax kg−1) during the submaximal cycle ergometer test. Adjusted means were compared between current, past, and never BB users. Current users were subsequently stratified by β-receptor selectivity and dose. Results: Compared to never use, current use was associated with a lower CRF, based on the 6MWT (current use: 569.7 m; never use: 580.4 m [ P = .010]), but not based on the cycling test (current use: 2.14 W kg−1; never use: 2.13 W kg−1 [ P = .690]). There was no difference between current selective and current nonselective BB use. Conclusion: β-Blockers use was associated with CRF based on the 6MWT but not the cycling test. There was no difference between current selective and nonselective BB users, possibly due to the small number of nonselective BB users, differential underlying diseases, other pharmacological properties, and limitations related to the proxies of the outcome. |
| Databáze: | OpenAIRE |
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