Osteopetrosis (Albers-Schonberg): appearance on three-phase bone scintigraphy
| Autor: | Mark M. Maslack, Richard A. Vitti, Daphne Roitberg |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.diagnostic_test
business.industry Osteomyelitis Autosomal dominant trait Osteopetrosis General Medicine Middle Aged Technetium Tc 99m Medronate Scintigraphy medicine.disease Osteochondrodysplasia Bone and Bones Bone scintigraphy medicine Humans Radiology Nuclear Medicine and imaging Female Radiopharmaceuticals Complication Nuclear medicine business Chest radiograph Radionuclide Imaging Genes Dominant |
| Zdroj: | Clinical nuclear medicine. 22(12) |
| ISSN: | 0363-9762 |
| Popis: | A 47-year-old woman with osteopetrosis, diagnosed incidentally 20 years earlier on a routine pre-employment chest radiograph, presented with painful knees of approximately 3 months' duration. A three-phase bone scan of the knees was performed using Tc-99m MDP for pathophysiologic evaluation of the patient's disease process and to rule out a complication such as fracture or osteomyelitis. The bone scan revealed bilateral hyperemia, as well as abnormal radiotracer accumulation in the distal femurs and proximal tibiae bilaterally, a reflection of her disease. No fractures or signs of modeling defects (i.e., Erlenmeyer flask), clubbing, or metaphyseal splaying were demonstrated. This suggested that she most likely had type 1 autosomal dominant disease variant by scintigraphic evaluation, and furthermore confirmed that the three-phase bone scan was a useful diagnostic test to characterize and distinguish between the two main phenotypic forms of the autosomal dominant form of osteopetrosis. |
| Databáze: | OpenAIRE |
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