Antipneumococcal activity of ertapenem compared with gatifloxacin in a temperature-sensitive murine model of acute pneumonia
| Autor: | J.C.S. De Azavedo, S.E. Walker, Darrin J. Bast, Don E. Low, C.L. Duncan, L. Dresser |
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| Rok vydání: | 2007 |
| Předmět: |
DNA Topoisomerase IV
Ertapenem medicine.drug_class Antibiotics Mice Inbred Strains medicine.disease_cause beta-Lactams Gatifloxacin Microbiology chemistry.chemical_compound Mice Streptococcus pneumoniae medicine Animals heterocyclic compounds Pharmacology (medical) Antibacterial agent Pharmacology biology Temperature Pneumonia Pneumococcal bacterial infections and mycoses medicine.disease Streptococcaceae biology.organism_classification Anti-Bacterial Agents Pneumonia Disease Models Animal Infectious Diseases Treatment Outcome Oncology chemistry Pneumococcal pneumonia Mutation medicine.drug Fluoroquinolones |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 19(4) |
| ISSN: | 1120-009X |
| Popis: | Fluoroquinolone-resistance among pneumococci is low; however the number of isolates with a single ParC mutation has increased. Consequently, more potent agents are needed to minimize resistance selection. We investigated the efficacy of ertapenem versus gatifloxacin in a temperature-sensitive mouse model of pneumonia caused by a wildtype Streptococcus pneumoniae strain (A66) and an isogenic mutant with a ParC mutation (R222). Treatment started at 24 h and lasted for 5 days. Temperature was used to assess disease progression before and during treatment. Of mice infected with either strain and treated at an early stage of infection, 79-94% of those given ertapenem survived compared with 56-61% given gatifloxacin. If treated at a later stage, the results were similar for ertapenem (71-84%) but were considerably lower for gatifloxacin (17-33%). Ertapenem was as bactericidal as gatifloxacin against A66 (94-100% vs 92-100%) but was superior to gatifloxacin against R222 (95-100% vs 50-77%). Ertapenem is a promising new treatment for patients with pneumococcal pneumonia, including those at risk of infection with a fluoroquinolone-resistant strain. |
| Databáze: | OpenAIRE |
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