Mitochondrion, lysosome, and endoplasmic reticulum: Which is the best target for phototherapy?

Autor:	Yan-Hong, Li, Hao-Ran, Jia, Hong-Yin, Wang, Xian-Wu, Hua, Yan-Wen, Bao, Fu-Gen, Wu
Rok vydání:	2022
Předmět:	Porphyrins Photosensitizing Agents Photochemotherapy Cell Line Tumor Pharmaceutical Science Phototherapy Endoplasmic Reticulum Lysosomes Mitochondria
Zdroj:	Journal of Controlled Release. 351:692-702
ISSN:	0168-3659
Popis:	Photodynamic therapy (PDT) is a robust cancer treatment modality, and the precise spatiotemporal control of its subcellular action site is crucial for its effectiveness. However, accurate comparison of the efficacy of different organelle-targeted PDT approaches is challenging since it is difficult to find a single system that can achieve separate targeting of different organelles with separable time windows and similar binding amounts. Herein, we conjugated chlorin e6 (Ce6) with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-5000] (ammonium salt) (DSPE-PEG
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7b22ede9b7c954a1990967085b6f64 https://doi.org/10.1016/j.jconrel.2022.09.037 Zobrazit plný text záznamu Full Text from ScienceDirect