Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives

Autor:	Julie Elizabeth Brumwell, Lal Chima, Wendy Dangerfield, Adrian Folkes, Pretswell Ian Andrew, Sukhjit Hunjan, Hamish Ryder, Michael Bryan Roe, Ashworth Philip Anthony, Peter Charlton
Rok vydání:	1999
Předmět:	medicine.drug_class Tariquidar Clinical Biochemistry Pharmaceutical Science Carboxamide Biochemistry Chemical synthesis Structure-Activity Relationship In vivo Drug Discovery medicine Tumor Cells Cultured Structure–activity relationship Humans ortho-Aminobenzoates ATP Binding Cassette Transporter Subfamily B Member 1 Molecular Biology P-glycoprotein biology Chemistry Organic Chemistry Drug Synergism In vitro Drug Resistance Multiple Multiple drug resistance Doxorubicin biology.protein Molecular Medicine medicine.drug
Zdroj:	Bioorganicmedicinal chemistry letters. 9(4)
ISSN:	0960-894X
Popis:	We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7b15c39737ef0af23fbc375ebc062f https://pubmed.ncbi.nlm.nih.gov/10098671 Zobrazit plný text záznamu Full Text from ScienceDirect