Maximum Standardized Uptake Value on 18F-Fluoro-2-Deoxy-Glucose Positron Emission Tomography/Computed Tomography and Glucose Transporter-1 Expression Correlates With Survival in Invasive Ductal Carcinoma of the Pancreas
| Autor: | Masatoshi Ishibashi, Hiroyuki Tanaka, Yoshinobu Okabe, Koji Okuda, Hisafumi Kinoshita, Yuhei Kitasato, Masayoshi Kage, Masafumi Yasunaga, Akihiko Kawahara, Hayato Kaida |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Fluorine Radioisotopes Pathology Endocrinology Diabetes and Metabolism medicine.medical_treatment Multimodal Imaging Endocrinology Single-Blind Method Epidermal growth factor receptor Aged 80 and over Glucose Transporter Type 1 Glucose Transporter Type 3 medicine.diagnostic_test biology Middle Aged Neoplasm Proteins ErbB Receptors 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography medicine.anatomical_structure Positron emission tomography Pancreatectomy Female maximum standardized uptake value Pancreas Carcinoma Pancreatic Ductal Adult medicine.medical_specialty Standardized uptake value Pancreaticoduodenectomy Fluorodeoxyglucose F18 glucose transporter 1 Preoperative Care glucose transporter 3 Internal Medicine medicine Humans invasive ductal carcinoma of the pancreas Survival analysis Aged Retrospective Studies Hepatology business.industry Glucose transporter Original Articles Survival Analysis carbohydrates (lipids) Pancreatic Neoplasms Positron-Emission Tomography biology.protein Radiopharmaceuticals Tomography X-Ray Computed epidermal growth factor receptor Nuclear medicine business |
| Zdroj: | Pancreas |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/mpa.0000000000000185 |
| Popis: | Objectives The purpose of this study was to assess the correlations among the maximum standardized uptake value (SUVmax) on 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT); the expressions of glucose transporter 1 (GLUT-1), glucose transporter 3, and epidermal growth factor receptor (EGFR); as well as prognosis in patients with invasive ductal carcinoma of the pancreas. Methods A total of 41 patients with surgically resected and histologically proven invasive ductal carcinoma of the pancreas who underwent preoperative FDG-PET/CT were assessed. The SUVmax at the primary tumor site was measured by FDG-PET/CT, and immunohistochemical staining of tumor sections was performed for GLUT-1, glucose transporter 3, and EGFR. Results Higher FDG uptake (SUVmax, >3.40) and GLUT-1 expression were significantly associated with shorter overall survival (P < 0.05). The SUVmax was not found to be significantly correlated with clinicopathological characteristics such as TNM classification, lymph node metastasis, and tumor differentiation. The EGFR expression was significantly correlated with the SUVmax (P = 0.024). Conclusions Higher FDG uptake and GLUT-1 expression in invasive ductal carcinoma of the pancreas seems to be an important prognostic factor. In addition, the EGFR expression was significantly correlated with the SUVmax. |
| Databáze: | OpenAIRE |
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