Association between the hydrogenase level and the occurrence of remote diffusion-weighted imaging lesions after spontaneous intracerebral hemorrhage
| Autor: | Mei-yuan Chen, Xiao-dong Lu, Zheng-xiang Hu, Dan-ning Lou, Xiao-chuan Wang, Meng-lu Zhou |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Gastroenterology Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Lactate dehydrogenase Internal medicine Medicine Effective diffusion coefficient Humans In patient cardiovascular diseases Spontaneous intracerebral hemorrhage Elevated ldh Aged Cerebral Hemorrhage Retrospective Studies Receiver operating characteristic L-Lactate Dehydrogenase business.industry General Medicine Middle Aged Signal on Diffusion Magnetic Resonance Imaging Neurology chemistry 030220 oncology & carcinogenesis Surgery Female Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers Diffusion MRI |
| Zdroj: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 77 |
| ISSN: | 1532-2653 |
| Popis: | To explore the influence of serum lactate dehydrogenase (LDH) level on remote diffusion-weighted imaging lesions (rDWILs) after spontaneous intracerebral hemorrhage (ICH). A consecutive cohort of 160 patients with spontaneous ICH who had brain MRI within 4 weeks of ICH onset were collected and analyzed retrospectively. rDWILs showed high signal on diffusion-weighted image (DWI) while low signal on apparent diffusion coefficient (ADC), and at least 20 mm away from the hemorrhage focus. The blood samples were obtained within 24 h after ICH onset from all patients. Lactate dehydrogenase (LDH) levels in blood were collected from serum biochemical tests. We use multivariate logistic regression analyses to investigate the association between serum LDH level and rDWILs after ICH. The average serum LDH level was 186.5 ± 35.6 U/L. And this level was higher in patients who presented rDWILs than in those without rDWILs. With the best cut-off value of 191 by using receiver operating characteristic (ROC) analysis, elevated LDH was associated with the presence of rDWILs independently (OR = 1.024, 95%CI = 1.011-1.037, P 0.001) in the bivariate logistic regression analysis with adjustment for age, sex, previous ischemic stroke/TIA, smoker, SBP on admission, hematoma volume, and intraventricular hemorrhage (IVH). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of LDH ≥ 191 U/L for rDWILs were 70.4%, 72.2%, 33.9%, 94.2%, respectively. Our study suggests serum LDH level has a significant correlation with rDWILs after spontaneous ICH. Patients with higher serum LDH level in 24 h after ICH onset may be a useful predictor for rDWILs occurrence. |
| Databáze: | OpenAIRE |
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