The association between iron and vitamin D status in Arab adolescents
| Autor: | Nasser M. Al-Daghri, Majed S. Alokail, Sobhy M. Yakout, Mohammad S. Masoud, Omar S. Al-Attas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Adolescent Iron Saudi Arabia Medicine (miscellaneous) Physiology Nutritional Status 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Vitamin D+Metabolites Sex Factors Vitamin D and neurology Medicine Humans Vitamin D Child Nutrition and Dietetics biology medicine.diagnostic_test Anemia Iron-Deficiency business.industry Transferrin saturation Cholesterol HDL Public Health Environmental and Occupational Health Anthropometry Micronutrient Vitamin D Deficiency Lipids Arabs Ferritin Cross-Sectional Studies Metabolic markers biology.protein Female business Lipid profile Research Paper |
| Zdroj: | Public Health Nutr |
| ISSN: | 1475-2727 1368-9800 |
| Popis: | Objective:Both vitamin D and Fe micronutrient deficiencies are common in Saudi Arabia but the association between them is unclear. The present study aimed to determine whether Fe indices are associated with vitamin D status and other metabolic markers in Arab adolescents.Design:Single-centre, cross-sectional study gathering anthropometrics, glucose and lipid profile. Serum 25-hydroxyvitamin D (25(OH)D), Fe, total iron-binding capacity (TIBC), transferrin saturation (%) and other parameters were measured.Setting:Vitamin D School Project Database, King Saud University (2014–2016).Participants:Arab adolescents aged 10–17 years randomly selected from the Vitamin D School Project Database (170 Saudi students; 100 girls, seventy boys).Results:Among Fe indices, only TIBC was found to be significantly and inversely associated with 25(OH)D (r = −0·20; P < 0·01) and only in girls (r = −0·20; P < 0·05). Among cardiometabolic parameters, serum Fe was associated with TAG in boys (r = 0·36; P < 0·01) and inversely associated with HDL-cholesterol in girls (r = −0·29; P < 0·05). Age was the most significant predictor of serum Fe for all participants, accounting for 5 % (R2 = 0·05; P = 0·004) of variance perceived. Serum 25(OH)D and age, on the other hand, were the most significant predictors for TIBC, accounting for 10·1 % (R2 = 0·10; P < 0·001) of variance perceived.Conclusions:Among healthy Arab adolescents, the association between vitamin D and Fe indices, particularly TIBC, is modest, inverse and sex-dependent. Larger studies with inclusion of markers such as hepcidin and ferritin, vitamin D metabolites and endogenous sex hormones may provide a clearer view of this complex association. |
| Databáze: | OpenAIRE |
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