Spatial Control of Gut-Specific Gene Expression During Caenorhabditis elegans Development
| Autor: | James D. McGhee, Eric J. Aamodt, May A. Chung |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Genetics
Regulation of gene expression Embryo Nonmammalian Multidisciplinary Lineage (genetic) biology digestive oral and skin physiology Repressor DNA biology.organism_classification Models Biological digestive system Gene Expression Regulation Enzymologic Carboxylesterase Organ Specificity Gene expression Caenorhabditis Animals Myocyte Chromosome Deletion Carboxylic Ester Hydrolases Digestive System Gene Caenorhabditis elegans |
| Zdroj: | Science. 252:579-582 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | The nematode Caenorhabditis elegans was transformed with constructs containing upstream deletions of the gut-specific ges-1 carboxylesterase gene. With particular deletions, ges-1 was expressed, not as normally in the gut, but rather in muscle cells of the pharynx (which belong to a sister lineage of the gut) or in body wall muscle and hypodermal cells (which belong to a cousin lineage of the gut). These observations suggest that gut-specific gene expression in C. elegans involves not only gut-specific activators but also multiple repressors that are present in particular nongut lineages. |
| Databáze: | OpenAIRE |
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