Adipogenic commitment induced by green tea polyphenols remodel adipocytes to a thermogenic phenotype
| Autor: | Ana Carolina Migliorini Figueira, Leticia Torres Ferreira, Anaysa Paola Bolin, Celso Pereira Batista Sousa-Filho, Gustavo Tolentino Nascimento dos Santos, Fernanda Aparecida Heleno Batista, Rosemari Otton, Paula Bresciani Martins de Andrade |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty FGF21 Endocrinology Diabetes and Metabolism Clinical Biochemistry Adipose tissue 030209 endocrinology & metabolism Inflammation Biology Biochemistry Camellia sinensis 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine AMP-Activated Protein Kinase Kinases Internal medicine Adipocyte medicine Animals Humans Adipocytes Beige Obesity Molecular Biology Nutrition and Dietetics Adipogenesis Futile cycle Lipogenesis AMPK Polyphenols Thermogenesis Fibroblast Growth Factors Mice Inbred C57BL PPAR gamma 030104 developmental biology Endocrinology chemistry Plant Preparations medicine.symptom Energy Metabolism Protein Kinases Signal Transduction |
| Zdroj: | The Journal of nutritional biochemistry. 83 |
| ISSN: | 1873-4847 |
| Popis: | The potential contribution of green tea (GT) to the development of thermogenic/beige cells have been scarcely investigated. Here we investigated if the beneficial effects of GT in the induction of thermogenic/beige adipocytes results from an initial cell commitment during adipogenesis. Male C57Bl/6 mice (3 months) were divided into 3 groups: Control (chow diet), Obese (cafeteria diet), and Obese + GT. Mice received GT gavage (500 mg/kg of BW) over 12 weeks (5 days/week), after 4 weeks of diet, totalizing 16 weeks of experimentation. GT treatment increased energy expenditure (EE) in mice fed with cafeteria-diet leading to reduced BW gain, decreased adiposity, reduced inflammation, and improving insulin sensitivity. Those phenotypes were associated with enhanced expression of oxidative, thermogenic and beige genes. GT induced a futile cycle through de novo lipogenesis activating the thermogenic pathway. Induction of beige phenotype occurs autonomously in adipocytes and involves the PPARγ/FGF21/AMPK/UCP1 pathway. Our study identified that metabolic changes caused by GT may involve the temporal expression of PPARγ promoting the induction of thermogenic cells by reprogramming initial steps of adipocyte commitment. |
| Databáze: | OpenAIRE |
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