Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats
| Autor: | Eric C.H. Ho, Samantha L. Payne, Jaclyn M. Obermeyer, Anup Tuladhar, Molly S. Shoichet, Cindi M. Morshead |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0206 medical engineering Biomedical Engineering Synaptophysin Bioengineering 02 engineering and technology Methylcellulose Biochemistry Biomaterials Rats Sprague-Dawley 03 medical and health sciences Drug Delivery Systems Polylactic Acid-Polyglycolic Acid Copolymer Neurotrophic factors medicine Animals Hyaluronic Acid Stroke 030304 developmental biology Brain-derived neurotrophic factor Neurons 0303 health sciences Behavior Animal business.industry Brain-Derived Neurotrophic Factor Brain Recovery of Function Tissue repair medicine.disease 020601 biomedical engineering Hindlimb Ischemic stroke business Neuroscience |
| Zdroj: | Tissue engineering. Part A. 25(15-16) |
| ISSN: | 1937-335X |
| Popis: | We developed a biocomposite that can be mixed with brain-derived neurotrophic factor (BDNF) and dispensed onto the surface of the brain to provide sustained, local release of the protein using a procedure that avoids additional damage to neural tissue. The composite is simple to fabricate, and provides sustained release without nanoparticle encapsulation of BDNF, preserving material and protein bioactivity. We demonstrate that when delivered epicortically to a rat model of stroke, this composite allows BDNF to diffuse into the brain, resulting in enhanced behavioral recovery and synaptic plasticity in the contralesional hemisphere. |
| Databáze: | OpenAIRE |
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