Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study
| Autor: | Helena Huerga, Mathieu Bastard, Alex Vicent Lubega, Milcah Akinyi, Natalia Tamayo Antabak, Liesbet Ohler, Winnie Muyindike, Ivan Mugisha Taremwa, Rosanna Stewart, Claire Bossard, Nothando Nkosi, Zibusiso Ndlovu, Catherine Hewison, Turyahabwe Stavia, Gordon Okomo, Jeremiah Okari Ogoro, Jacqueline Ngozo, Mduduzi Mbatha, Couto Aleny, Stephen Wanjala, Mohammed Musoke, Daniel Atwine, Alexandra Ascorra, Elisa Ardizzoni, Martina Casenghi, Gabriella Ferlazzo, Lydia Nakiyingi, Ankur Gupta-Wright, Maryline Bonnet |
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| Přispěvatelé: | Epicentre [Paris] [Médecins Sans Frontières], Epicentre Ouganda [Mbarara] [Médecins Sans Frontières], Médecins sans Frontières [Nairobi, Kenya], Médecins Sans Frontières [Cape Town, South Africa], Médecins Sans Frontières [Paris] (MSF), Uganda Ministry of Health, Ministry of Health [Nairobi, Kenya], Ministry of Health [Mozambique], Institute of Tropical Medicine [Antwerp] (ITM), Elizabeth Glaser Pediatric AIDS Foundation, Makerere University College of Health Sciences, University College of London [London] (UCL), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), This study was funded by the ANRS (grant number 20314) and Médecins Sans Frontières. FujiLAM tests were donated by the Foundation for Innovative Diagnostics. |
| Rok vydání: | 2022 |
| Předmět: |
MESH: Humans
MESH: Mycobacterium tuberculosis MESH: African People MESH: South Africa MESH: CD4 Lymphocyte Count MESH: Tuberculosis [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: HIV Infections General Medicine MESH: Lipopolysaccharides MESH: Female MESH: Male MESH: Sensitivity and Specificity |
| Zdroj: | The Lancet global health The Lancet global health, 2023, 11 (1), pp.e126-e135. ⟨10.1016/S2214-109X(22)00463-6⟩ |
| ISSN: | 2214-109X |
| DOI: | 10.1016/S2214-109X(22)00463-6⟩ |
| Popis: | International audience; Background: Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnostic accuracy of the novel Fujifilm SILVAMP TB LAM (FujiLAM) assay with the WHO-recommended Alere Determine TB-LAM Ag test (AlereLAM) using urine samples from HIV-positive patients.Methods: We did a diagnostic accuracy study at five outpatient public health facilities in Uganda, Kenya, Mozambique, and South Africa. Eligible patients were ambulatory HIV-positive individuals (aged ≥15 years) with symptoms of tuberculosis irrespective of their CD4 T-cell count (group 1), and asymptomatic patients with advanced HIV disease (CD4 count |
| Databáze: | OpenAIRE |
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