Plasma renin activity in patients with coarctation of the aorta. A comment of the pathogenesis prestenotic hypertension
| Autor: | Etzel Gysling, Peter Weidmann, Manfred Schönbeck, Pierre Wirz, Klaus Baumann, Claus Werning, Walter Siegenthaler |
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| Rok vydání: | 1969 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Posture Coarctation of the aorta Aorta Thoracic Kidney Plasma renin activity Aortic Coarctation Renal Veins Constriction Physiology (medical) Internal medicine medicine.artery Renin medicine Humans Aorta business.industry Angiotensin II Blood Pressure Determination Venous blood medicine.disease Peripheral Stenosis Blood pressure Hypertension Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 40(5) |
| ISSN: | 0009-7322 |
| Popis: | In 10 patients with coarctation of the aorta, plasma renin activity was measured after recumbency and orthostatism in peripheral venous blood and, in some cases, in renal venous blood also. In nine of these patients, basic plasma renin values and those obtained under stimulatory conditions lay within normal range, and only in one patient were the values elevated. However, since this patient displayed the lowest gradient of mean arterial blood pressure proximal and distal to the stenosis, it can be regarded as improbable that the elevation in plasma renin activity was caused by the coarctation. Plasma renin activity in the renal venous blood of both kidneys, which was measured in three patients, showed no elevation. On the basis of observations of other authors and of our own studies it can be concluded that the kidneys can contribute to the development of prestenotic hypertension in acute constriction of the aorta in experiments with animals, but in chronic coarctation in animals or in man the humoral or renal theory has no importance to the pathogenesis of hypertension. |
| Databáze: | OpenAIRE |
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