Trabeculectomy, Phacoemulsification, and Posterior Chamber Lens Implantation With and Without 5-Fluorouracil
| Autor: | John M. O'Grady, Ronald P. Swendris, Lance C Lemon, Dong H. Shin, Mark S Juzych |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Intraocular pressure
medicine.medical_specialty medicine.medical_treatment Visual Acuity Trabeculectomy Cataract Extraction Injections Ophthalmology medicine Humans Prospective Studies Intraocular Pressure Aged Lenses Intraocular business.industry Phacoemulsification Prognosis Posterior chamber lens Surgery Postoperative visit Fluorouracil Total dose Chronic Disease Mann–Whitney U test business Conjunctiva Glaucoma Open-Angle Follow-Up Studies medicine.drug |
| Zdroj: | American Journal of Ophthalmology. 116:594-599 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/s0002-9394(14)73202-7 |
| Popis: | Subconjunctival 5-fluorouracil has been an effective adjunct in glaucoma filtering surgery. We investigated the effectiveness of 5-fluorouracil in primary trabeculectomy combined with phacoemulsification and posterior chamber intraocular lens implantation (glaucoma triple procedure). Seventy-four patients were enrolled and randomly assigned into two groups to receive either no 5-fluorouracil (control patients) or low-dose 5-fluorouracil (mean total dose, 24.8 mg; mean number of injections, 5.0 +/- 1.3). The mean preoperative intraocular pressure was 20.1 +/- 5.4 mm Hg for the 5-fluorouracil group and 21.0 +/- 5.2 mm Hg for the control group (P = .48, Student's unpaired t-test). The mean number of medications was 2.2 +/- 1.0 and 2.0 +/- 1.0 (P = .49, Mann Whitney U test), respectively. At all postoperative visits, there were no statistically significant differences in mean intraocular pressures between the two groups. Mean follow-up was 13.2 months for 5-fluorouracil-treated patients and 15.0 months for control patients. At the last postoperative visit, mean intraocular pressures were 15.4 +/- 3.7 mm Hg and 15.0 +/- 5.0 mm Hg, respectively (P = .45, Student's unpaired t-test). Both groups showed comparable visual outcome (20/40 or better in 31 of 38 5-fluorouracil-treated patients [82%] vs 32 of 36 control patients [89%]) and a decrease in number of medications needed, 0.7 +/- 1.0 and 0.7 +/- 0.9, respectively (P = .96, Mann Whitney U test). Thus, 5-fluorouracil administered as in our study did not seem to have any effect in primary trabeculectomy combined with phacoemulsification and posterior chamber intraocular lens implantation. |
| Databáze: | OpenAIRE |
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