Lung diffusion capacity in advanced heart failure: relation to central haemodynamics and outcome

Autor: Finn Gustafsson, Tania Deis, Louise Balling, Kasper Rossing, Emil Wolsk, Michael Perch
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Vital capacity
medicine.medical_specialty
Pulmonary Circulation
Denmark
Population
Heart failure
030204 cardiovascular system & hematology
Ventricular Function
Left
03 medical and health sciences
FEV1/FVC ratio
0302 clinical medicine
DLCO
medicine.artery
Internal medicine
Original Research Articles
Forced Expiratory Volume
Medicine
Humans
030212 general & internal medicine
Original Research Article
Pulmonary diffusion capacity
Pulmonary Wedge Pressure
Right heart catheterization
education
Pulmonary wedge pressure
Retrospective Studies
Heart Failure
education.field_of_study
Haemodynamics
business.industry
Hemodynamics
respiratory system
Middle Aged
medicine.disease
Respiratory Function Tests
Survival Rate
Pulmonary diffusion
Pulmonary artery
Cardiology
Pulmonary Diffusing Capacity
Female
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Zdroj: ESC Heart Failure
Deis, T, Balling, L, Rossing, K, Wolsk, E, Perch, M & Gustafsson, F 2019, ' Lung diffusion capacity in advanced heart failure : relation to central haemodynamics and outcome ', ESC heart failure, vol. 6, no. 2, pp. 379-387 . https://doi.org/10.1002/ehf2.12401
ISSN: 2055-5822
DOI: 10.1002/ehf2.12401
Popis: Aims: Patients with heart failure (HF) are known to have a reduced pulmonary diffusion capacity for carbon monoxide (D LCO ), but little is known about how lung function relates to central haemodynamics. The aim of this study was to investigate the association between haemodynamic variables and pulmonary diffusion capacity adjusted for alveolar volume in congestive HF patients and to analyse how predicted D LCO /V A affects mortality in relation to the haemodynamic status. Methods and results: We retrospectively studied right heart catheterization (RHC) and lung function data on 262 HF patients (mean age 51 ± 13 years) with a left ventricular ejection fraction LCO /V A , forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV 1 ), and haemodynamic parameters [pulmonary capillary wedge pressure (PCWP), central venous pressure, cardiac index, mean pulmonary artery pressure, and mean arterial pressure] as well as other factors known to affect lung function in HF. FEV 1 was reduced to LCO/ V A was reduced in 63% of the population. D LCO /V A correlated positively with pulmonary capillary wedge pressure in both univariate and multivariate analyses for all included patients (P LCO /V A predicted mortality in multivariate models [hazard ratio 1.5 (1.1–2.1)] but not the combined endpoint of death, LVAD implantation, or HTX. There was no significant correlation between haemodynamics and predicted FVC or FEV 1 . Conclusions: Pulmonary diffusion capacity correlates positively with left ventricular fillings pressures, and reduced values predict increased mortality in patients with HF. This might be driven by increased lung capillary volume in patients with pulmonary congestion.
Databáze: OpenAIRE
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