Plasma Concentrations of Clozapine and its Major Metabolites During Combined Treatment with Paroxetine or Sertraline
| Autor: | Maria Ancione, Maria Gabriella Scordo, Aldo G. Madia, Monica Salemi, Gabriella Facciolà, Angela Avenoso, Edoardo Spina |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male CYP2D6 Schizoaffective disorder Pharmacology Pharmacokinetics Sertraline medicine Humans Drug Interactions Pharmacology (medical) Clozapine business.industry General Medicine Middle Aged Drug interaction medicine.disease Paroxetine Psychiatry and Mental health Psychotic Disorders Schizophrenia Drug Therapy Combination Female Serotonin Antagonists business Reuptake inhibitor Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Pharmacopsychiatry. 33:213-217 |
| ISSN: | 1439-0795 0176-3679 |
| DOI: | 10.1055/s-2000-8361 |
| Popis: | The effect of paroxetine or sertraline on steady-state plasma concentrations of clozapine and its major metabolites was studied in 17 patients with schizophrenia or schizoaffective disorder stabilized on clozapine therapy (200-400 mg/day). In order to treat negative symptomatology or concomitant depression, 9 patients received additional paroxetine (20-40mg/day) and 8 patients sertraline (50-100 mg/day). After 3 weeks of paroxetine administration, mean plasma concentrations of clozapine and norclozapine increased significantly by 31% (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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