Comparison of dipyridamole and treadmill exercise for enhancing thallium-201 perfusion defects in patients with coronary artery disease
| Autor: | D. A. Chamberlain, S. K. Strak, P. Gishen, A D Timmis, R. J. Burwood, L. J. Fenney, J. E. Lutkin |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Physical Exertion chemistry.chemical_element Coronary Disease Treadmill exercise Chest pain Coronary artery disease Angina Internal medicine Humans Medicine Thallium Treadmill Radionuclide Imaging Radioisotopes business.industry Myocardium Dipyridamole medicine.disease chemistry Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business Perfusion medicine.drug |
| Zdroj: | European Heart Journal. 1:275-280 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/oxfordjournals.eurheartj.a061130 |
| Popis: | Dipyridamole was compared with exercise as a method of enhancing myocardial perfusion defects on thallium-201 scintiscans. Twenty patients with angina had scans after treadmill exercise to near the limit of effort tolerance, and again 4 h later in the redistribution phase. On a separate occasion the same patients had scans after intravenous dipyridamole 0.6 mg/kg. Fifteen of them were also investigated by coronary angiography. Exercise and drug-induced coronary dilatation caused segmental abnormalities of similar degree but the anatomical areas showing these perfusion defects correlated less well. Neither technique offered any clear advantage over the other in predicting the site of coronary stenosis, or in the quality of images obtained. Unwanted drug effects after intravenous dipyridamole were minor but included chest pain in four patients. Intravenous dipyridamole can reasonably be used instead of exercise for thallium-201 scintiscans. The technique will be of particular value when exercise testing is impracticable. |
| Databáze: | OpenAIRE |
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