Anti-Fel d1 immunoglobulin Y antibody-containing egg ingredient lowers allergen levels in cat saliva
| Autor: | Scott Sherrill, Peichuan Sun, Ebenezer Satyaraj, Qinghong Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Saliva
Immunoglobulins Enzyme-Linked Immunosorbent Assay medicine.disease_cause Immunoglobulin E 03 medical and health sciences Ingredient chicken IgY 0302 clinical medicine Allergen medicine Animals Small Animals Glycoproteins 030304 developmental biology Air Pollutants 0303 health sciences Fel d1 biology Chemistry allergies to cats Antibodies Monoclonal Original Articles Allergens 030228 respiratory system Current management Immunology Human allergy Cats biology.protein Immunoglobulin Y Cat allergen Antibody diet allergen |
| Zdroj: | Journal of Feline Medicine and Surgery |
| ISSN: | 1532-2750 1098-612X |
| Popis: | Objectives Fel d1 is the major cat allergen, causing IgE reactions in up to 90% of cat-allergic adults. Fel d1 secreted in saliva is spread to the haircoat during grooming. Current management includes attempts to reduce or eliminate exposure to Fel d1. A novel approach to reducing immunologically active Fel d1 (aFel d1) exposure, which involves binding the Fel d1 with an anti-Fel d1-specific polyclonal egg IgY antibody (sIgY), was evaluated. The hypothesis was that saliva from cats fed diets containing this sIgY would show a significant reduction in aFel d1. Methods Two trials in cats were completed. In trial 1, saliva was collected 0, 1, 3 and 5 h post-feeding during a 2 week baseline and subsequent 6 week treatment period. Trial 2 included a control and treatment group, and saliva was collected once daily. Trial 2 cats were fed the control diet during a 1 week baseline period, and then fed either control or sIgY diet during the 4 week treatment period. Fel d1-specific ELISA was used to measure salivary aFel d1. Data were analysed using repeated-measures ANOVA and a linear mixed-model analysis. Results Salivary aFel d1 decreased post-treatment in both trials. There were no differences in aFel d1 based on time of collection relative to feeding in trial 1. In trial 2, 82% of treatment group cats showed a decrease in aFel d1 of at least 20% from baseline vs just 38% of control cats. Only one (9%) treatment cat showed an increase in aFel d1 vs 63% of control cats. Conclusions and relevance Feeding sIgY significantly reduced aFel d1 in the saliva of cats within 3 weeks. Although additional research is needed, these findings show promise for an alternative approach to the management of allergies to cats. |
| Databáze: | OpenAIRE |
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