Release of 5-hydroxytryptamine (5-HT) from medullary and mesencephalic raphé neurones after grafting to the rat hippocampus: Evidence for regulation by 5-HT1A autoreceptors
| Autor: | G.A. Foster, Trevor Sharp |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Serotonin
medicine.medical_specialty Microdialysis Tetrahydronaphthalenes 5 7-Dihydroxytryptamine Hippocampus Hippocampal formation Biology Fetal Tissue Transplantation Mesencephalon Internal medicine medicine Animals Brain Tissue Transplantation Neurons 8-Hydroxy-2-(di-n-propylamino)tetralin Medulla Oblongata Raphe General Neuroscience Rats Inbred Strains Rats Endocrinology nervous system Receptors Serotonin Autoreceptor Medulla oblongata Raphe Nuclei Raphe nuclei Neuroscience |
| Zdroj: | Neuroscience Letters. 132:179-182 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(91)90296-6 |
| Popis: | The overflow and metabolism of serotonin (5-HT) from transplants of embryonic medullary and mesencephalic raphe neurones in the previously 5-HT-denervated hippocampus have been analyzed in vivo using microdialysis. Output of 5-HT and its metabolite 5-hydroxyindolacetic acid (5-HIAA) from such grafts was as great (medullary) or greater (mesencephalic) than that measured in the normal intact hippocampus. Systemic administration of the putative 5-HT 1A receptor agonist 8-hydroxy-2-(di- n -propylamino)tetralin (8-OH-DPAT) led to a 50–80% reduction in 5-HT levels in hippocampal dialysates from both intact and raphe grafted hippocampus. Since 8-OH-DPAT normally reduces 5-HT release from the nerve terminal via activation at the somatodendritic 5-HT 1A autoreceptor and subsequent inhibition of impulse flow, the results indicate that 5-HT output from both medullary and mesencephalic raphe grafts can be regulated by autoreceptors and is dependent on serotoninergic neuronal activity. |
| Databáze: | OpenAIRE |
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