New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
| Autor: | Wenhan Lin, Werner E.G. Müller, Sherif S. Ebada, Peter Proksch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Stereochemistry Pharmaceutical Science 01 natural sciences jasplakinolide Z5 Drug Discovery Jaspis splendens Ic50 values Cytotoxic T cell Spectral analysis Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 cytotoxic activity biology 010405 organic chemistry Chemistry 010604 marine biology & hydrobiology Mouse Lymphoma biology.organism_classification In vitro 0104 chemical sciences Sponge lcsh:Biology (General) Two-dimensional nuclear magnetic resonance spectroscopy jasplakinolide Z6 |
| Zdroj: | Marine Drugs Volume 17 Issue 2 Marine Drugs, Vol 17, Iss 2, p 100 (2019) |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md17020100 |
| Popis: | A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC50 values in the low micromolar to nanomolar range. |
| Databáze: | OpenAIRE |
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