Multi‐wavelength, handheld laser speckle imaging for skin evaluation
| Autor: | Marco De Gregorio, Andreas Wuttig, Sarmiza Elena Stanca, Martin Sattler, Carina Reble, Rainer Riesenberg, Michael Zieger, Robin Sieg, Georg Khazaka, Frank Fischer, Steffen Springer, Mario Kanka, Martin Kaatz |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Skin ageing
Materials science Lasers Human skin Multi wavelength Laser Speckle Imaging Dermatology Laser 01 natural sciences Skin Aging law.invention 010309 optics Laser Speckle Contrast Imaging 030207 dermatology & venereal diseases 03 medical and health sciences Speckle pattern 0302 clinical medicine Methyl nicotinate law 0103 physical sciences Humans Speckle imaging Skin Biomedical engineering |
| Zdroj: | Skin Research and Technology. 27:486-493 |
| ISSN: | 1600-0846 0909-752X |
| DOI: | 10.1111/srt.12959 |
| Popis: | Objective A handheld device was developed and qualified for in vivo human skin evaluation using laser speckle imaging technology. Methods Each laser speckle device prototype allows the choice of up to three different laser wavelengths in the range of 400 nm to 800 nm in total. Speckle pattern analysis gives various speckle parameters, for example, speckle contrast, speckle size, speckle modulation or fractal dimension. The developed laser speckle device prototypes were evaluated investigating three skin issues. Results We receive reproducible results from the speckle imaging device. For skin ageing, we found significant changes within three age groups. The effect of a methyl nicotinate treatment was clearly visible and quantifiable using a moorFLPI device as well as our speckle imaging device. In terms of basal cell carcinoma diagnosis, we found significant differences between normal and diseased skin, even though the number of samples was limited. Conclusion As shown with first application examples, it was possible to demonstrate the potential of the method for skin evaluation in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|