Prefrontal cortical thickness and clinical characteristics of long-term treatment response to valproate in bipolar disorder
| Autor: | Valente Cedillo-Ríos, Joanna Jiménez-Pavón, Fátima Meza-Urzúa, Claudia Becerra-Palars, María Margarita López-Titla, Alejandra Monserrat Rodríguez-Ramírez, César Leonardo Sánchez-Segura, Hiram Ortega-Ortiz, Beatriz Camarena-Medellín, Maria de Lourdes Martínez-Gudiño, Pamela Morales-Cedillo |
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| Rok vydání: | 2021 |
| Předmět: |
Cerebral Cortex
Treatment response medicine.medical_specialty Bipolar Disorder Long term treatment medicine.diagnostic_test business.industry Valproic Acid Neuroscience (miscellaneous) Prefrontal Cortex Magnetic resonance imaging Frontal eye fields Logistic regression medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Mood disorders Neuroimaging Internal medicine medicine Cardiology Humans Radiology Nuclear Medicine and imaging Bipolar disorder business |
| Zdroj: | Psychiatry Research: Neuroimaging. 317:111382 |
| ISSN: | 0925-4927 |
| Popis: | Valproate compositions are frequently used to treat bipolar disorder (BD); however, 87% of patients do not report full response in the long-term. There is scarce information about the clinical features and brain structural characteristics of long-term treatment response (LTTR) to this medication. In this study, we aim to evaluate the clinical characteristics and prefrontal cortical thickness (CT) of LTTR to valproate in BD. We evaluated 30 BD outpatients on valproate treatment, and 20 controls with a 3T T1-weighted 3D brain scan and Alda's scale for LTTR. An analysis of covariance was used to evaluate CT measures and a logistic regression was conducted to predict the full response (FR) using clinical features and CT measures. Patients with an insufficient response (IR) reported thinner right frontal eye fields, anterior and dorsolateral prefrontal cortexes compared with controls. FR patients presented thicker right dorsolateral prefrontal cortex than IR and no differences with controls. Patients with mixed features presented increased odds of achieving FR, while CT measures reported non-significant results. This is the first study to report mixed features as a clinical predictor of valproate LTTR. Our findings also suggest better preservation of the right prefrontal cortex of subjects with FR to valproate. |
| Databáze: | OpenAIRE |
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