Erythropoietin Promotes Neural Plasticity and Spatial Memory Recovery in Fimbria-Fornix-Lesioned Rats
| Autor: | Esteban Alberti-Amador, Daymara Mercerón-Martínez, Rilda Leon-Martinez, Jorge A. Bergado Rosado, Nuris Ledón, Nancy Pavón-Fuentes, Susana Delgado Ocaña, William Almaguer-Melian |
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| Rok vydání: | 2015 |
| Předmět: |
MAPK/ERK pathway
Male medicine.medical_specialty Time Factors Fornix Brain Muscle Proteins Water maze Lesion Hemoglobins hemic and lymphatic diseases Internal medicine Neuroplasticity Medicine Animals Rats Wistar Maze Learning Erythropoietin Brain-derived neurotrophic factor Analysis of Variance Memory Disorders Arc (protein) Neuronal Plasticity business.industry Brain-Derived Neurotrophic Factor General Medicine Recovery of Function Rats Disease Models Animal Endocrinology Gene Expression Regulation Brain Injuries Signal transduction medicine.symptom business Apoptosis Regulatory Proteins Neuroscience medicine.drug |
| Zdroj: | Neurorehabilitation and neural repair. 29(10) |
| ISSN: | 1552-6844 |
| Popis: | Background. Erythropoietin (EPO) upregulates the mitogen activated protein kinase (MAPK) cascade, a central signaling pathway in cellular plastic mechanisms, and is critical for normal brain development. Objective. We hypothesized that EPO could modulate the plasticity mechanisms supporting spatial memory recovery in fimbria-fornix-transected animals. Methods. Fimbria-fornix was transected in 3 groups of rats. Seven days later, EPO was injected daily for 4 consecutive days within 10 minutes after training on a water maze task. Results. Our results show that EPO injections 10 minutes after training produced a substantial spatial memory recovery in fimbria-fornix-lesioned animals. In contrast, an EPO injection shortly after fimbria-fornix lesion surgery does not promote spatial-memory recovery. Neither does daily EPO injection 5 hours after the water maze performance. EPO, on the other hand, induced the expression of plasticity-related genes like arc and bdnf, but this effect was independent of training or lesion. Conclusions. This finding supports our working hypothesis that EPO can modulate transient neuroplastic mechanisms triggered by training in lesioned animals. Consequently, we propose that EPO administration can be a useful trophic factor to promote neural restoration when given in combination with training. |
| Databáze: | OpenAIRE |
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