Renin-angiotensin blockade reduces serum free testosterone in middle-aged men on haemodialysis and correlates with erythropoietin resistance
| Autor: | Kim-Chong Yong, Michael J. Delong, Yeong-Hau H. Lien, Joy L. Logan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Drug Resistance Angiotensin-Converting Enzyme Inhibitors Sex Factors Renal Dialysis Internal medicine Renin–angiotensin system Medicine Humans Testosterone Erythropoietin Aged Aged 80 and over Transplantation business.industry Age Factors Testosterone (patch) Middle Aged medicine.disease Androgen Recombinant Proteins Blockade Epoetin Alfa Endocrinology Nephrology Case-Control Studies Hematinics Kidney Failure Chronic Female Hemodialysis business Angiotensin II Type 1 Receptor Blockers Kidney disease Hormone medicine.drug |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 20(3) |
| ISSN: | 0931-0509 |
| Popis: | Background. There are conflicting reports about the importance of the renin–angiotensin system (RAS) on erythropoietin (Epo) sensitivity in haemodialysis patients, but the role of gender has not been studied specifically. The hypothesis underlying this study is that Epo resistance associated with RAS blockade (RASB) is specific to men and related to drug-induced lowering of circulating testosterone. Methods. Men and women undergoing chronic haemodialysis were divided into groups according to whether or not they were receiving RASB. Serum was collected pre-dialysis for determination of free testosterone levels by enzyme immunoassay. Routine laboratory data and Epo doses were collated and analysed for the 3 month period prior to the measurement of the hormone level. Results. Control women required more Epo than control men (P ¼ 0.002), but the Epo doses between men and women with RASB were similar. Men with RASB required more Epo than control men (P ¼ 0.002), but RASB had no effect on Epo requirements in women. There was a significant relationship between age and testosterone levels in control men (P ¼ 0.01) that was not present in men taking RASB. RASB was associated with lower levels of serum testosterone in men |
| Databáze: | OpenAIRE |
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