Anti-inflammatory properties of the stem bark from the herbal drug Vitex peduncularis Wall. ex Schauer and characterization of its polyphenolic profile
| Autor: | Federico Ferreres, Paula B. Andrade, Nelson G.M. Gomes, Patrícia Valentão, Sutsawat Duangsrisai, David M. Pereira, Rungcharn Suksungworn, Kiattawee Choowongkomon, Angel Gil-Izquierdo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Drug
medicine.drug_class media_common.quotation_subject Anti-Inflammatory Agents Toxicology 01 natural sciences Flavones Anti-inflammatory Vitex Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Botany medicine Animals media_common chemistry.chemical_classification Stem bark biology Traditional medicine Plant Extracts 010405 organic chemistry Macrophages Polyphenols General Medicine biology.organism_classification 0104 chemical sciences RAW 264.7 Cells chemistry Polyphenol 030220 oncology & carcinogenesis Apigenin Plant Bark Luteolin Food Science |
| Zdroj: | Food and Chemical Toxicology. 106:8-16 |
| ISSN: | 0278-6915 |
| Popis: | Vitex spp. have been reported as constituents of herbal preparations, namely Vitex peduncularis, commonly used in Asian countries. Unlike other species extensively investigated, reports on the biological activities and chemical profile of V. peduncularis are still scarce. In this work, the polyphenolic profile of V. peduncularis stem bark was unveiled, revealing a high content of apigenin and luteolin derivatives. More than 20 polyphenols were identified and quantitated for the first time, including C-rhamnosyl flavones infrequently reported. Regarding potential anti-inflammatory properties, the methanolic extract of the stem bark significantly reduced the levels of NO in macrophages, which may be a consequence of scavenging effect upon •NO. Significant inhibition of phospholipase A2 activity was also noted. Consequently, the therapeutic applicability of this edible plant is also broadened due to the anti-inflammatory properties found. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect