Measurement of MR signal and T2* in lung to characterize a tight skin mouse model of emphysema using single-point imaging
| Autor: | Malin Palmér, Lars B Johansson, Leif Hultin, Lars E. Olsson, Paul D. Hockings, Martina Kvist Reimer, Maria Lindahl, Per-Ola Onnervik |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Signal Mice Imaging Three-Dimensional In vivo Parenchyma medicine Image Processing Computer-Assisted Animals Radiology Nuclear Medicine and imaging Lung Emphysema medicine.diagnostic_test Chemistry business.industry Age Factors Magnetic resonance imaging Histology Signal Processing Computer-Assisted respiratory system Magnetic Resonance Imaging Disease Models Animal medicine.anatomical_structure Disease Progression Tight skin Tomography Nuclear medicine business Tomography X-Ray Computed |
| Zdroj: | Journal of magnetic resonance imaging : JMRI. 25(3) |
| ISSN: | 1053-1807 |
| Popis: | PURPOSE: To evaluate whether MRI signal and T2* measurements of lung tissue acquired at ultrashort detection times (tds) can detect emphysematous changes in lungs.MATERIALS AND METHODS: MR signal intensity of in vivo mouse lungs was measured at 4.7 T at tds of 0.2 and 0.4 msec using single-point imaging (SPI). T2* was calculated from the measurements obtained at the two tds. Two groups of 8- and 30-week-old Tight Skin (TS) and aged-matched CB57BL/6 mice were examined. The TS mice spontaneously developed emphysema-like alveolar enlargement. In vivo micro-computed tomography (microCT) scanning and histology were used as reference methods.RESULTS: MR signal and T2* were significantly lower in the lungs of TS mice than in controls. There were no significant differences between the different age groups. MR signal in lung parenchyma correlated linearly (P < 0.0001, r = 0.89) with microCT mass density, and T2* correlated linearly (P < 0.0001, r = -0.91) with the alveoli size (mean linear intercept [MLI]).CONCLUSION: The MR signal intensity and T2* measured at short tds can be used as imaging biomarkers to characterize parenchyma density and alveolar size, respectively. (Less) |
| Databáze: | OpenAIRE |
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