Bactericidal Activities of HMR 3647, Moxifloxacin, and Rifapentine against Mycobacterium leprae in Mice
| Autor: | Pascale Bonnafous, Sophie Consigny, Baohong Ji, Jacques H. Grosset, Abdelhalim Bentoucha |
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| Rok vydání: | 2000 |
| Předmět: |
Ketolides
medicine.drug_class Moxifloxacin Antibiotics Leprostatic Agents Microbial Sensitivity Tests Biology Pharmacology Microbiology Mice Anti-Infective Agents Leprosy Clarithromycin medicine Animals Experimental Therapeutics Pharmacology (medical) Mycobacterium leprae Skin Antibacterial agent Aza Compounds Foot biology.organism_classification Rifapentine Anti-Bacterial Agents Infectious Diseases Quinolines Female Macrolides Ofloxacin Rifampin Rifampicin Fluoroquinolones medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 44:2919-2921 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.44.10.2919-2921.2000 |
| Popis: | Bactericidal activities of HMR 3647 (HMR), moxifloxacin (MXFX), and rifapentine (RPT) against Mycobacterium leprae , measured by the proportional bactericidal technique in the mouse footpad system, were compared with those of the established antileprosy drugs clarithromycin (CLARI), ofloxacin (OFLO), and rifampin (RMP). Administered in five daily doses of 100 mg/kg of body weight, HMR appeared slightly more bactericidal than CLARI. In a single dose, MXFX at 150 mg/kg was more active than the same dose of OFLO and displayed exactly the same level of activity as RMP at 10 mg/kg; the combination MXFX-minocycline (MINO) (MM) was more bactericidal than the combination OFLO-MINO (OM); RPT at 10 mg/kg was more bactericidal than the same dose of RMP and even more active than the combination RMP-OFLO-MINO (ROM); the combination RPT-MXFX-MINO (PMM) killed 99.9% of viable M. leprae and was slightly more bactericidal than RPT alone, indicating that the combination PMM showed an additive effect against M. leprae . |
| Databáze: | OpenAIRE |
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