Insights in the pathophysiology of haemorrhagic strokes in a sub-Sahara African country, an epidemiological and MRI study
| Autor: | Charlotte Damien, M. Saw, Mohamed Lamine Toure, M. Konaté, Fodé Abass Cissé, Noemie Ligot, S.D. Barry, Gilles Naeije |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty hypertension 030231 tropical medicine stroke outcome 03 medical and health sciences 0302 clinical medicine Belgium Risk Factors Internal medicine Neurologie Epidemiology medicine Humans cerebral haemorrhage Prospective Studies Prospective cohort study Imagerie médicale radiologie tomographie cerebral amyloid angiopathy Aged Cerebral Hemorrhage Retrospective Studies Aged 80 and over business.industry Mortality rate Public Health Environmental and Occupational Health Middle Aged Epidémiologie medicine.disease Magnetic Resonance Imaging Pathophysiology Cerebral Amyloid Angiopathy Infectious Diseases Cohort Hypertension Africa Parasitology Female Guinea epidemiology Cerebral amyloid angiopathy business Mri findings Amyloid angiopathy |
| Zdroj: | Tropical Medicine & International Health |
| Popis: | Objective: Intra-cerebral Haemorrhage (ICH) seems more prevalent in sub-Saharan Africa (SSA) than in High-Income Countries (HIC) with poorer clinical outcome. Higher impact of hypertension and/or amyloid angiopathy could account for this disproportion. Here, we sought to (i) retrospectively compare ICH clinical and imaging patterns in Belgium and Guinea and in a subsequent cohort (ii) prospectively compare brain MRI characteristics to seek evidence for a different proportion of amyloid angiopathy patterns. Methods: Ninety one consecutive patients admitted for spontaneous ICH at Brussels Erasme-ULB Hospital and at Conakry Ignace Deen-UGANC were retrospectively compared in terms of ICH volume estimated with the ABC/2 method, clinical characteristics and modified ranking (mRS) score at 30 days. mRS was dichotomised as good outcomes (≤3) and poor outcomes (>3). A prospective cohort of 30 consecutive patients with ICH admitted at CHU Conakry Ignace Deen-UGANC was prospectively included to undergo brain MRI. Results of the Guinean MRI were compared to 30 patients randomly selected from Brussels’ initial cohort. Paired Student’s t-test and Mann–Whitney u-test were used for group comparisons. Results: Age of ICH onset was higher in Belgium (68 ± 17 years vs. 56 ± 14 years, P SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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