Lipid profile in the first-degree relatives of patients with precocious coronary heart disease in Rohtak area (Northern India)
| Autor: | Sushil Ahlawat, Suyash Mohan, Sanjay Gupta, Siwach Sb |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Very low-density lipoprotein medicine.medical_specialty Adolescent Cholesterol VLDL Hyperlipidemia Familial Combined India Coronary Disease Gastroenterology chemistry.chemical_compound High-density lipoprotein Internal medicine Hyperlipidemia medicine Cluster Analysis Humans First-degree relatives Risk factor Child Triglycerides medicine.diagnostic_test Cholesterol business.industry Incidence Cholesterol HDL Cholesterol LDL medicine.disease Lipids Coronary heart disease Endocrinology chemistry lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine Lipid profile business |
| Zdroj: | Angiology. 46(1) |
| ISSN: | 0003-3197 |
| Popis: | Twenty-five patients with precocious coronary heart disease (CHD) (aged forty years or less) and 82 first-degree relatives were studied for lipid profile. Eighty-eight age- and sex-matched controls were also studied. The mean serum cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, and total cholesterol/high density lipoprotein cholesterol of patients and their first-degree relatives were significantly higher as compared with normal controls. High density lipoprotein cholesterol values were found to be almost identical in the patient group, their first-degree relatives, and normal controls. Hyperlipidemia was found in 68% of patients with CAD, of their first-degree relatives, and 24% of controls. Almost all lipid fractions in relatives of hyperlipidemic patients paralleled those of the patients suffering from CHD. Of 25 families studied, 16 had hyperlipidemia. In conclusion, it can be stated that there is a statistically significant hyperlipidemia in young patients with CHD that has a significant familial clustering, thus delineating a group of high-risk individuals (first-degree relatives of young coronary patients) for possible primary prevention of CHD. This familial clustering could be due to genetic or environmental factors; however, the relative contribution of these two factors requires further investigation. |
| Databáze: | OpenAIRE |
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