Low-dose computed tomography (LDCT) in workers previously exposed to asbestos: detection of parenchymal lung disease
| Autor: | Elsie T. Nguyen, Demetris Patsios, Stephen J. Herman, Samira Alturkistany, Heidi C. Roberts, Tae Bong Chung, Maria Claudia Carrillo, Gordon L. Weisbrod, Narinder Paul |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Mesothelioma medicine.medical_specialty Lung Neoplasms Radiography Computed tomography Comorbidity medicine.disease_cause Radiation Dosage Asymptomatic Sensitivity and Specificity Asbestos Risk Factors medicine Prevalence Humans Radiology Nuclear Medicine and imaging Lung cancer Aged Aged 80 and over Ontario Lung medicine.diagnostic_test business.industry Smoking Reproducibility of Results Environmental Exposure Middle Aged medicine.disease medicine.anatomical_structure Asbestosis Female Radiology medicine.symptom business Tomography X-Ray Computed Environmental Monitoring |
| Zdroj: | Journal of computer assisted tomography. 37(4) |
| ISSN: | 1532-3145 |
| Popis: | Objectives To evaluate the lungs of asymptomatic asbestos-exposed workers who were screened for lung cancer and mesothelioma using low-dose computed tomography (LDCT) for parenchymal abnormalities. Methods Three hundred fifteen baseline LDCT studies of the chest of participants with at least 20 years' exposure to asbestos or presence of pleural plaques before enrollment on chest radiographs were analyzed. Results Three hundred fifteen subjects were studied. The mean age was 61.7 years, and the mean exposure to asbestos was 26.9 years. One hundred seventy-five (56%) participants had absence of parenchymal findings with a mean age of 58.7 years, mean exposure of 24.6 years, and a mean smoking pack years of 19. One hundred forty subjects (44%) had parenchymal findings (138 men and 2 women) with a mean age of 65.3 years, mean exposure of 29.73 years, and a mean smoking pack years of 21.5 years. Participants who had parenchymal manifestations were more likely to be older and have longer exposure to asbestos compared to participants who had no relevant parenchymal findings. There was no statistical difference in the mean smoking pack years between the groups with and without parenchymal findings. Conclusions Low-dose CT could demonstrate parenchymal lung manifestations in this higher-risk asymptomatic group with prior exposure to asbestos in the setting of screening for lung cancer and mesothelioma. Individuals with longer exposure to asbestos and of higher age have more pulmonary abnormalities. The age and the latency of exposure play an important role given that the asbestos-related parenchymal abnormalities on LDCT were more prevalent in the elderly participants and with longer periods of exposure. |
| Databáze: | OpenAIRE |
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