FTY720 (Fingolimod) has an antiproliferative effect on human Glioblastoma cells alone and in combination with Temozolomide but does not influence the expression of EMT-related genes

Autor: Gött, H, Nagl, J, Santhiyanesan, S, Seemann, C, Schwarm, FP, Uhl, E, Stein, M, Kolodziej, MA
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCV082 /20220525/
DOI: 10.3205/22dgnc085
Popis: Objective: FTY720 as immunomodulative drug has also an impact on cell signaling pathways involved in cell proliferation and survival, and several studies suggest an effect on epithelial to mesenchymal transition (EMT) pathways. In this study we investigated the antiproliferative effect of FTY720 on [for full text, please go to the a.m. URL]
Databáze: OpenAIRE