The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice
| Autor: | Baisong Lu, Qingguo Zhao, Changjie Han |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Clinical Biochemistry Mutant Adipose tissue Biochemistry Eating Mice chemistry.chemical_compound 0302 clinical medicine Food intake NOS nitric oxide synthase Inner mitochondrial membrane Cyclic GMP lcsh:QH301-705.5 Cells Cultured Immp2l IMP2 inner mitochondrial membrane peptidase-like chemistry.chemical_classification Regulation of gene expression 0303 health sciences lcsh:R5-920 Superoxide Brain UCP2 uncoupling protein 2 Adipose Tissue Female Signal transduction lcsh:Medicine (General) Signal Transduction Research Paper medicine.medical_specialty CART cocaine- and amphetamine-regulated transcript NPY neuropeptide Y CYC1 cytochrome c1 POMC pro-opiomelanocortin Biology Nitric oxide Mitochondrial Proteins 03 medical and health sciences ROS reactive oxygen species AMPK AMP-activated protein kinase Internal medicine Endopeptidases medicine Animals AgRP agouti related protein GPD2 mitochondrial glycerol phosphate dehydrogenase 030304 developmental biology Mutant mice NO nitric oxide Reactive oxygen species Body Weight Organic Chemistry ADSC adipose-derived stromal cells Endocrinology Gene Expression Regulation chemistry lcsh:Biology (General) Mutation Immp2l cGMP cyclic guanosine monophosphate Energy expenditure Reactive Oxygen Species 030217 neurology & neurosurgery |
| Zdroj: | Redox Biology, Vol 1, Iss 1, Pp 498-507 (2013) Redox Biology |
| ISSN: | 2213-2317 |
| Popis: | Reactive oxygen species have been implicated in feeding control through involvement in brain lipid sensing, and regulating NPY/AgRP and pro-opiomelanocortin (POMC) neurons, although the underlying mechanisms are unclear. Nitric oxide is a signaling molecule in neurons and it stimulates feeding in many species. Whether reactive oxygen species affect feeding through interaction with nitric oxide is unclear. We previously reported that Immp2l mutation in mice causes excessive mitochondrial superoxide generation, which causes infertility and early signs of aging. In our present study, reduced food intake in mutant mice resulted in significantly reduced body weight and fat composition while energy expenditure remained unchanged. Lysate from mutant brain showed a significant decrease in cGMP levels, suggesting insufficient nitric oxide signaling. Thus, our data suggests that reactive oxygen species may regulate food intake through modulating the bioavailability of nitric oxide. Graphical abstract Highlights • Mature adult Immp2l mutant mice have reduced body weight and fat composition. • Reduced body weight and fat composition is caused by reduced food intake. • Energy expenditure is not affected in mutant mice. • Brain cGMP level is lower in mutant mice. |
| Databáze: | OpenAIRE |
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