The Adenovirus Death Protein – A small membrane protein controls cell lysis and disease
| Autor: | Fanny Georgi, Urs F. Greber |
|---|---|
| Přispěvatelé: | University of Zurich, Greber, Urs F |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
1303 Biochemistry
Biophysics Biology Endoplasmic Reticulum Biochemistry Adenoviridae Adenovirus Infections Human 1307 Cell Biology 03 medical and health sciences symbols.namesake Immune system 1315 Structural Biology 1311 Genetics Immunity Structural Biology Adenovirus E3 Proteins 1312 Molecular Biology Genetics Animals Humans human adenovirus Molecular Biology 030304 developmental biology 0303 health sciences membrane rupture Endoplasmic reticulum 030302 biochemistry & molecular biology virus transmission apoptosis virus egress Adenovirus Death Protein Cell Biology Golgi apparatus Virology 10124 Institute of Molecular Life Sciences Oncolytic virus cell death Membrane protein Apoptosis oncolytic viruses Host-Pathogen Interactions Mad2 Proteins symbols 570 Life sciences biology cancer therapy cell lysis Adenovirus death protein 1304 Biophysics |
| DOI: | 10.5167/uzh-188168 |
| Popis: | Human adenoviruses (HAdVs) cause widespread acute and persistent infections. Infections are usually mild and controlled by humoral and cell-based immunity. Reactivation of persistently infected immune cells can lead to a life-threatening disease in immunocompromised individuals, especially children and transplant recipients. To date, no effective therapy or vaccine against HAdV disease is available to the public. HAdV-C2 and C5 are the best-studied of more than 100 HAdV types. They persist in infected cells and release their progeny by host cell lysis to neighbouring cells and fluids, a process facilitated by the adenovirus death protein (ADP). ADP consists of about 100 amino acids and harbours a single membrane-spanning domain. It undergoes post-translational processing in endoplasmic reticulum and Golgi compartments, before localizing to the inner nuclear membrane. Here, we discuss the current knowledge on how ADP induces membrane rupture. Membrane rupture is essential for both progression of disease and efficacy of therapeutic viruses in clinical applications, in particular oncolytic therapy. |
| Databáze: | OpenAIRE |
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