Alveolar and Postcranial Bone Density in Postmenopausal Women Receiving Hormone/Estrogen Replacement Therapy
| Autor: | Reina Armamento-Villareal, Mary Dotson, Roberto Civitelli, N. Yokoyama-Crothers, Sheldon Cohen, Jane Muckerman, Thomas K. Pilgram, Nancy Lewandowski, Charles F. Hildebolt, E. Eugenia Kardaris, Jay Hauser |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Bone density Bone disease Osteoporosis Alveolar Bone Loss Urology Medroxyprogesterone Acetate Absorptiometry Photon Double-Blind Method Bone Density Internal medicine Internal Medicine medicine Humans Medroxyprogesterone acetate Femur Osteoporosis Postmenopausal Dental alveolus Aged Bone mineral Estrogens Conjugated (USP) Lumbar Vertebrae Trochanter business.industry Estrogen Replacement Therapy Middle Aged medicine.disease Endocrinology Multivariate Analysis Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0003-9926 |
| Popis: | Background: We conducted a 3-year, double-blind, randomized, placebo-controlled study to determine whether the positive effects of hormone/estrogen replacement therapy (H/ERT) on postcranial bone density are accompanied by similar positive effects on oral bone mass. Methods: A total of 135 postmenopausal women (aged 41-70 years) with no evidence of moderate or severe periodontal disease were randomized to receive daily oral conjugated estrogen (Premarin; 0.625 mg) alone or in combination with medroxyprogesterone acetate (Prempro; 0.625 and 2.5 mg, respectively) or placebo. All subjects received calcium carbonate (1000 mg/d) and cholecalciferol (800 IU/d) supplements. The primary efficacy end points were the changes in alveolar crest height and alveolar bone density. Alveolar crest height was measured on bite-wing radiographs, and changes in alveolar bone mass were assessed by means of digital-subtraction radiography. Postcranial bone density was measured in the lumbar spine and left proximal femur by means of dualenergy x-ray absorptiometry. Results: Hormone/estrogen replacement therapy significantly increased alveolar bone mass compared with placebo (+1.84% vs +0.95% [P=.04]), and tended to improve alveolar crest height (+4.83% vs +3.46% [P=.34]). Bone mineral density of the proximal femur significantly increased in the H/ERT compared with the placebo group (total proximal femur, +3.59% vs +0.22% [P=.001]; neck, +2.05% vs �0.34% [P=.02]; trochanter, +3.49% vs +0.08% [P.001]), but not the lumbar spine (+1.01% vs +0.17% [P=.39]). Changes in alveolar bone mass correlated with bone density changes in the total femur (r=0.28 [P=.02]) and femoral trochanter (r=0.25 [P=.04]) in the H/ERT but not in the placebo group. Conclusions: Postcranial and oral bone mass were increased in postmenopausal women receiving H/ERT. Improvement in oral bone health constitutes an additional benefit of H/ERT. |
| Databáze: | OpenAIRE |
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