Bone marrow/bone pre-metastatic niche for breast cancer cells colonization: The role of mesenchymal stromal cells
| Autor: | Natalia Pacienza, María Belén Giorello, María Cecilia Sanmartin, Norma Alejandra Chasseing, Francisco Raúl Borzone, Gustavo Yannarelli |
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| Rok vydání: | 2021 |
| Předmět: |
Stromal cell
business.industry Niche Mesenchymal stem cell Bone metastasis Bone Neoplasms Breast Neoplasms Mesenchymal Stem Cells Hematology medicine.disease Breast cancer medicine.anatomical_structure Oncology Bone Marrow Cancer research Tumor Microenvironment Medicine Humans Colonization Female Bone marrow Breast cancer cells Breast Stromal Cells business |
| Zdroj: | Critical reviews in oncology/hematology. 164 |
| ISSN: | 1879-0461 |
| Popis: | Breast cancer is one of the most common oncological pathologies in women worldwide. While its early diagnosis has considerably improved, about 70 % of advanced patients develop bone metastases with a high mortality rate. Several authors demonstrated that primary breast cancer cells prepare their future metastatic niche –known as the pre-metastatic niche- to turn it into an “optimal soil” for colonization. The role of the different cellular components of the bone marrow/bone niche in bone metastasis has been well described. However, studying the changes that occur in this microenvironment before tumor cells arrival has become a novel research field. Therefore, the purpose of this review is to describe the current knowledge about the modulation of the normal bone marrow/bone niche by the primary breast tumor, in particular, highlighting the role of mesenchymal stem/stromal cells in transforming this soil into a pre-metastatic niche for breast cancer cells colonization. |
| Databáze: | OpenAIRE |
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