Dynamic dopaminergic regulation of neuropeptide Y systems in discrete striatal and accumbens regions
| Autor: | John D. Wagstaff, James W. Gibb, Glen R. Hanson, Lloyd G. Bush, Nanda A. Singh, Leonora P. Midgley |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Dopamine Agents Neuropeptide FF receptor Neuropeptide Striatum Nucleus accumbens Globus Pallidus Basal Ganglia Nucleus Accumbens Rats Sprague-Dawley Dopamine receptor D1 Dopamine receptor D2 Internal medicine Limbic System medicine Animals Neuropeptide Y Extrapyramidal Tracts Neurons Pharmacology Receptors Dopamine D2 Chemistry Receptors Dopamine D1 Putamen Benzazepines Neuropeptide Y receptor Corpus Striatum Stimulation Chemical Rats Dopamine D2 Receptor Antagonists Endocrinology nervous system Dopamine receptor Sulpiride |
| Zdroj: | European Journal of Pharmacology. 251:191-199 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(94)90400-6 |
| Popis: | In this study we evaluated the effects of multiple administrations of selective dopamine D1 and D2 receptor agonists and antagonists on striatal, nigral, accumbens, pallidal and cortical neuropeptide Y systems. Treatment with the D1 receptor agonist, SKF 38393, decreased, while that with the D1 receptor antagonist, SCH 23390, increased neuropeptides Y-like immunoreactivity in the globus pallidus and several regions within the caudate-putamen. SCH 23390 did not change accumbens neuropeptide Y-like immunoreactivity levels but SKF 38393 increased neuropeptide Y-like immunoreactivity levels in anterior and decreased neuropeptide Y-like immunoreactivity levels in the posterior nucleus accumbens. Interestingly, reductions in neuropeptide Y-like immunoreactivity content occurred in response to administrations of both D2 receptor agonist, quinpirole, or antagonist, sulpiride, in all identified regions of eacj structure at some time point. These data suggest that the neuropeptide Y systems studied may be regulated by selective activity at postsynaptic or presynaptic dopamine receptors. They further suggest that within structures such as the caudate-putamen and nucleus accumbens are multiple distinct neuropeptide Y systems which are uniquely influenced by dopamine receptors. |
| Databáze: | OpenAIRE |
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