Metabolic and behavioral consequences of lidocaine-kindled seizures
| Autor: | D.H. Ingvar, M. Miyaoka, Robert M. Post, Sumio Suda, M. Shinohara, Charles Kennedy, K. Squillace, Leon Sokoloff |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Glucose utilization medicine.medical_specialty Lidocaine Hippocampus Amygdala Limbic system Seizures Internal medicine medicine Limbic System Animals Humans Molecular Biology Electroshock Kindling General Neuroscience Deoxyglucose Rats Inbred Strains Rats Aggression medicine.anatomical_structure Endocrinology Glucose nervous system Decreased glucose Anesthesia Pentylenetetrazole Neurology (clinical) Psychology Developmental Biology medicine.drug |
| Zdroj: | Brain research. 324(2) |
| ISSN: | 0006-8993 |
| Popis: | Daily administration of lidocaine results in progressive increases in frequency and duration of convulsions in response to a dose of drug which was previously subconvulsive--a pharmacological kindling phenomenon. The effects of such lidocaine-kindling on local cerebral glucose utilization were determined by the 2-[14C]deoxyglucose method. Lidocaine-treated animals, in the absence of convulsions, exhibited decreased glucose utilization in most brain structures compared to saline-treated animals and showed no increase in aggressive behavior. In animals displaying lidocaine-kindled convulsions there were marked increases in glucose utilization in either the hippocampus and amygdala or in perirhinal cortical areas during the seizure administration; these animals also displayed long-lasting increases in irritable behavior. Seizure duration was positively correlated with the rate of glucose utilization in the hippocampus, amygdala and septum, but inversely correlated in several non-limbic areas. These data suggest that lidocaine-kindled seizures are highly localized to limbic and perirhinal structures and are associated with important behavioral consequences. |
| Databáze: | OpenAIRE |
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