Serum and follicular fluid irisin levels in women with polycystic ovaries undergoing ovarian stimulation: correlation with insulin resistance and lipoprotein lipid profiles

Autor:	Anthia Chasiakou, Styliani Demeridou, Rachil Kapeta-Kourkouli, Evangelos Benidis, Stavroula Baka, Artemis Bousmpoula, Evangelia Kouskouni, Stamatia Chasiakou
Rok vydání:	2019
Předmět:	Adult medicine.medical_specialty endocrine system diseases Lipoproteins Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Ovulation Induction Pregnancy Internal medicine Myokine medicine Humans Dyslipidemias 030219 obstetrics & reproductive medicine business.industry nutritional and metabolic diseases Obstetrics and Gynecology Lipid Metabolism medicine.disease Lipids Polycystic ovary Follicular fluid female genital diseases and pregnancy complications Fibronectins Follicular Fluid Case-Control Studies Female Insulin Resistance business Infertility Female Body mass index Dyslipidemia Polycystic Ovary Syndrome Lipoprotein
Zdroj:	Gynecological Endocrinology. 35:803-806
ISSN:	1473-0766 0951-3590
DOI:	10.1080/09513590.2019.1594761
Popis:	Irisin, a novel exercise-induced myokine, has been implicated in different aspects of human metabolism and could be connected to polycystic ovary syndrome (PCOS). This study aimed to investigate serum and follicular fluid (FF) irisin levels in PCOS and normal women undergoing controlled ovarian stimulation and correlate them to the lipid and lipoprotein levels as well as with other metabolic parameters. Serum and FF irisin, together with serum lipid and lipoprotein levels were assessed in 70 women with diagnosed PCOS and 70 non-PCOS controls, under in vitro fertilization (IVF) treatment. Regardless of BMI, PCOS women had a significantly increased number of oocytes retrieved, fertilized oocytes and transferred embryos, although the number of women achieving pregnancies did not differ between groups. No correlation between FF irisin levels and pregnancy could be established. Serum and FF irisin levels were significantly higher in PCOS and overweight women and were positively associated with BMI and dyslipidemia. FF irisin levels correlated positively to and were lower than serum irisin levels. Further research would be helpful to analyze irisin's role in female reproduction, if any, as well as in human metabolism and the pathophysiology of PCOS.
Databáze:	OpenAIRE
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