MYC as a regulator of ribosome biogenesis and protein synthesis
| Autor: | Jan van Riggelen, Dean W. Felsher, Alper Yetil |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Ribosomal Proteins
Models Genetic Applied Mathematics General Mathematics 5.8S ribosomal RNA Regulator Genes myc Ribosome biogenesis RNA Ribosomal RNA Biology Ribosome Cell biology Proto-Oncogene Proteins c-myc Gene Expression Regulation Neoplasms Protein Biosynthesis Transcriptional regulation Protein biosynthesis Homeostasis Humans RNA Messenger Ribosomes |
| Zdroj: | Nature reviews. Cancer. 10(4) |
| ISSN: | 1474-1768 |
| Popis: | Recently, MYC has been shown to serve as a direct regulator of ribosome biogenesis and therefore coordinates protein synthesis. Could the regulation of ribosome biogenesis by MYC be necessary for its role in tumorigenesis? MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis. |
| Databáze: | OpenAIRE |
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