The immune checkpoint receptor associated phosphatases SHP-1 and SHP-2 are not required for γδT17 cell development, activation, or skin inflammation
| Autor: | John Rizk, Darshana Kadekar, Rasmus Agerholm, Monica Torrellas Viñals, Vasileios Bekiaris |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology chemical and pharmacologic phenomena Inflammation Context (language use) Mice Transgenic Protein Tyrosine Phosphatase Non-Receptor Type 11 Development Biology Lymphocyte Activation γδ T cells 03 medical and health sciences Mice 0302 clinical medicine SHP medicine Immunology and Allergy Animals Receptor Skin Cell growth Protein Tyrosine Phosphatase Non-Receptor Type 6 Skin inflammation Receptors Antigen T-Cell gamma-delta Immune checkpoint Cell biology IL-17 030104 developmental biology Cytokine Th17 Cells Interleukin 17 biological phenomena cell phenomena and immunity medicine.symptom Cell activation 030215 immunology |
| Zdroj: | Kadekar, D D, Agerholm, R, Viñals, M T, Rizk, J A M B & Bekiaris, V 2020, ' The immune checkpoint receptor associated phosphatases SHP-1 and SHP-2 are not required for γδ T17 cell development, activation or skin inflammation ', European Journal of Immunology, vol. 50, no. 6, pp. 873-879 . https://doi.org/10.1002/eji.201948456 |
| ISSN: | 1521-4141 |
| DOI: | 10.1002/eji.201948456 |
| Popis: | Interleukin(IL)-17 producing gamma delta (γδT17) cells are innate lymphocytes critical for anti-bacterial protection at barrier surfaces such as the skin but also highly pathogenic during inflammation. It is therefore important to understand the cellular and molecular mechanisms that could counter-balance overt γδT17 cell activation. Immune checkpoint receptors (ICRs) deliver inhibitory signals to activated lymphocytes and have been implicated as negative regulators of mouse γδT17 cells. In this report we investigated the cytokine signals that induce ICR expression on γδT17 cells and studied the in vivo role of the Src-homology-2 phosphatases 1 and 2 (SHP-1 and SHP-2) in the context of γδT17-induced psoriasis. We found that surface expression of ICRs can be induced by cytokines, however, SHP-1 or SHP-2 could not inhibit γδT17 responses. In this regard, conditional deletion of SHP-1, SHP-2 or both did no impact γδT17 cell development, expansion, cytokine production or skin pathology. This article is protected by copyright. |
| Databáze: | OpenAIRE |
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