Advances in Topical Hemostatic Agent Therapies: A Comprehensive Update
| Autor: | Alan D. Kaye, Liang Huang, Henry Liu, Geoffrey Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
030213 general clinical medicine
medicine.medical_specialty Administration Topical Hemorrhage Fibrin Tissue Adhesive Topical hemostatic agent Hemostatics Fibrin Hypoxemia 03 medical and health sciences 0302 clinical medicine Humans Medicine Pharmacology (medical) Intensive care medicine Hemostasis Hemostatic Agent biology business.industry General Medicine Clotting cascade Clinical Practice 030220 oncology & carcinogenesis Chemical agents biology.protein medicine.symptom business |
| Zdroj: | Advances in Therapy. 37:4132-4148 |
| ISSN: | 1865-8652 0741-238X |
| DOI: | 10.1007/s12325-020-01467-y |
| Popis: | Severe hemorrhage causes significant metabolic and cellular dysfunction secondary to deficient tissue perfusion and oxygen delivery. If bleeding continues, hemodynamic destabilization, hypoxemia, multiple organ failure, and death will occur. Techniques employed to promote hemostasis include surgical suture ligatures, cautery, chemical agents, self-assembling nanoparticles, and physical methods, like mechanical pressure. Improved understanding of the natural clotting cascade has allowed newly designed agents to become more targeted for clinical and military use. Topically-applied hemostatic agents have enormous clinical applications in achieving hemostasis. This manuscript describes currently available and developing topical hemostatic materials, including topical active agents, mechanical agents, synthetic/hemisynthetic hemostatic agents, and external hemostatic dressings for clinical practice. |
| Databáze: | OpenAIRE |
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